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-synuclein, which can be a primary part of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, that is an E3 ubiquitin ligase and causes endoplasmic reticulum (ER) worry, propose that dysfunction on the intracellular proteinase techniques, like ubiquitin-proteasome system or lysosomal process, which removes pointless poisonous proteins i
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